Professor
Lise Bjørkhaug Gundersen
Field of work
I am a molecular biologisk and work with understanding the pathological link between genetics and development of diabetes. I teach Pathology at the Biomedical Laboratory Sciences education (bachelor level) and strive to motivate the students to understand the association between cause and disease development of various forms for disease, treatment and prognosis. I engage bachelor, master and phd students in research projects where aim is to understand the effect of gene damage for the development of inherited forms of diabetes, or effect of biomarkers on sports performance (interdisciplinary projects).
- Pathology (BSc)
- Advanced biomedical analytical methods (MSc/EVU)
- Inherited (monogenic) diabetes and genetics
- Type 2 diabetes and genetics
- Health and performance in sports
Publications
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Acute response in circulating microRNAs following a single bout of short-sprint and heavy strength training in well-trained cyclists
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Functional characterization of HNF4A gene variants identify promoter and cell line specific transactivation effects
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Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes
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A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
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The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations
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Diabetes mellitus – analyser av genvarianter assosiert med subtyper av Maturity-Onset Diabetes of the Young (MODY)
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Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants
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The Female Menstrual Cycles Effect on Strength and Power Parameters in High-Level Female Team Athletes
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Incidence of HNF1A and GCK MODY Variants in a South African Population
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Unsupervised clustering of missense variants in HNF1A using multidimensional functional data aids clinical interpretation
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Functional Analyses of HNF1A-MODY Variants Refine the Interpretation of Identified Sequence Variants
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Open online E-learning resources at epraksis.no as preparation for hands-on laboratory practice
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Functional characterization of diabetes gene variants is important for precision medicine
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E-learning facilitates flipped learning and portofolio assessment in biomedical laboratory science
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Functional characterization of HNF1A variants identified in Norwegian MODY diabetes registry can implement precision medicine in diabetes clinics
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Significance of functional studies of HNF- gene coding variants for diabetes classification
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Handballstjerna håpar ny mensenforsking kan gi svar på kva som gjekk gale
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ePraksis film om Histologisk seksjon, Patologisk avdeling (HUS)
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The E3 SUMO ligase PIAS is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1
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Functional characterization of HNF1A variants identified in Norwegian diabetes registries can be important for precision medicine in diabetes clinics
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Etbalering av mikrobiopsiteknikk på muskel (vastus lateralis)
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The E3 SUMO ligase PIASy is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1a
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A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells
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Spektrofotometri 5 - Instrumenter
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Spektrofotometri 4 - Absorpsjon _ Eksitasjon
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Spektrofotometri 3 - Kromatorer
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Spektrofotometri 2 - Absorpsjonsspektrofotometer
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Spektrofotometri 1 - Lys og foton
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Studenter var involvert i utvikling av nytt molekylærpatologisk laboratoriekurs
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The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes
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Developing high throughput assays for functional classification of novel missense variants in HNF1A
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The E3 SUMO ligase PIASy regulates the activity and stability of the transcription factor hepatocyte nuclear factor 1-alpha
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Functional characterization of all HNF4A variants in the Norwegian MODY and the Norwegian Childhood Diabetes Registries
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Muskelbiopsi - status HVL
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Functional analysis of various HNF4A variants identifies increased transactivation function of R85W causing the mutation specific phenotype of neonatal hyperinsulinism and Fanconi syndrome
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Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation
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In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins
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Restriksjons enzym og analyse av DNA
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Functional investigations of HNF1A identify rare variants as risk factors for type 2 diabetes in the general population
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Structure–function studies of HNF1A (MODY3) gene mutations in South Indian patients with monogenic diabetes
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DNA analyser
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Hvordan isolere og rense DNA
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Kvantitative analyser - Standard addisjon
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Kvantitative analyser - Ekstern standard
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Kvantitative analyser
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Genvarianter som risikofaktorer for diabetes
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Analysis of protein-coding genetic variation in 60,706 humans.
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The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity
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High incidence of heterozygous ABCC8 and HNF1A mutations in Czech patients with congenital hyperinsulinism
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Association of a low-frequency variant in HNF1A with type 2 diabetes in a latino population the SIGMA Type 2 Diabetes Consortium
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STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity
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GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation
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Monogenetic diabetes mellitus in Norway :
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SUMOylation of pancreatic glucokinase regulates its cellular stability and activity
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GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation
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Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE
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Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity
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Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry
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Catalytic activation of human glucokinase by substrate binding - residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions
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Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation
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Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction
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A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry
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From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation
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Functional dissection of the HNF-1alpha transcription factor: A study on nuclear localization and transcriptional activation
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Molekylærgenetisk diagnostikk ved diabetes mellitus
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Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway
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Permanent neonatal diabetes caused by glucokinase deficiency; inborn error of the glucose-insulin signaling pathway
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N EONATAL D IABETES M ELLITUS D UE TO C OMPLETE G LUCOKINASE D EFICIENCY
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A simple test for the hot spot mutation P291fsinsC in MODY3
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MODY associated with two novel hepatocyte nuclear factor 1 alpha loss of function mutations
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A new candidate region for the positional cloning of the XLP gene
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The interaction between human FcgammaRI and the gamma-chain is mediated solely by the 21 amino acid transmembrane domain of FcgammaRI