Arbeids- og kompetanseområde
Jeg har erfaring fra grunn- og anvendt forsking innen fysiologi, farmakologi og biomedisin og adminisrasjon som forskningsrådgivning.
Min allsidige faglige bakgrunn inkluderer akvakulturutdanning ved Høgskolesenteret i Bodø, Cand. scient. i komparativ fysiologi (miljøfysiologi), med hovedfagsoppgave innen respirasjonsfysiologi ved Universitetet i Bergen (UiB) og Dr. philos. grad i molekylær hjertebiologi/farmakologi/fysiologi fra Farmakologisk institutt, Universitetet i Oslo (UiO).
Etter gjennomført dr. philos. grad ved UiO med fokus på endringer i genekspresjon, reseptorfunksjon og kontraktilitet ved hjertesvikt med bruk av humant hjertevev og dyremodeller, har jeg forskererfaring som post doktor ved Biomedisinsk institutt, UiB og forsker ved Nasjonalt senter for ernæring og sjømatforskning.
Har emneansvar for:
BIO101 Danning og akademisk handverk
BIO206 Medisinsk laboratorieteknologi III
BIO305 Profesjonsetikk og kommunikasjon
Har veilederansvar i:
BIO207 Ekstern praksis 1
BIO350 Bacheloroppgave - Bioingeniør
Har hatt emneansvar for:
BIO201 Hematologi og Immunologi
Ut over farmakologisk forskning i molekylær hjertebiologi/fysiologi kan forskningsaktiviteten oppsummeres med evaluering av effekten av ernæring og miljøgifter på biologisk utvikling og livsstilsykdommer i ulike dyremodeller (innavlede, villtyper og «knoc out») med blant annet fokus på endringer i DNA og miRNA ekspresjon og epi-genetikk.
Publikasjonar
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Gir bioingeniørutdanningene gode redskaper for å håndtere og forebygge krenkelser?
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Improving animal research: PREPARE before you ARRIVE
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PREPARE: guidelines for planning animal research and testing
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Macronutrient composition determines accumulation of persistent organic pollutants from dietary exposure in adipose tissue of mice
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Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice
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A water-soluble extract of chicken reduced plasma triacylglycerols, but showed no anti-atherosclerotic activity in apoE<sup>-/-</sup> mice
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The Role of Persistent Organic Pollutants in Induction of Endoplasmic Reticulum Stress in Hepatocytes in vitro and in vivo
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Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice
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B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion
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Hypolipidemic effect of dietary water-soluble protein extract from chicken: impact on genes regulating hepatic lipid and bile acid metabolism
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The cardioprotective effect of the modern Atlantic salmon - dietary spillover from fish
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The role of seafood intake in late pregnancy on mercury levels in hair of mothers and their infants
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Hypolipidemic effect of dietary water-soluble protein extract from chicken: impact on genes regulating hepatic lipid and bile acid metabolism
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A salmon protein hydrolysate exerts lipid-independent anti-atherosclerotic activity in apoE-deficient mice
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Environmental contaminants in mother and child - Is there a correlation between mothers seafood intake and levels of environmental persistent organic contaminants in mother and child at 3, 6 and 12 months post partum
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Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α
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Intake of Farmed Atlantic Salmon Fed Soybean Oil Increases Insulin Resistance and Hepatic Lipid Accumulation in Mice
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alpha HBCD: Effect or no effect - A matter of diet?
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An immunomodulating fatty acid analogue targeting mitochondria exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in apoE(-/-) mice
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Fish Oil and the Pan-PPAR Agonist Tetradecylthioacetic Acid Affect the Amino Acid and Carnitine Metabolism in Rats
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Net production of Atlantic salmon (FIFO, Fish in Fish out < 1) with dietary plant proteins and vegetable oils
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Intake of farmed atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice
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Krill powder increases liver lipid catabolism and reduces glucose mobilization in tumor necrosis factor-alpha transgenic mice fed a high-fat diet
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The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure
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Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet
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Quantification of GPCR mRNA Using Real-Time RT-PCR
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Cerebral gene expression in response to single or combined gestational exposure to methylmercury and selenium through the maternal diet
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Cerebral gene expression and neurobehavioural development after perinatal exposure to an environmentally relevant polybrominated diphenylether (BDE47)
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Normalization strategy is critical for the outcome of miRNA expression analyses in the rat heart
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Fish consumption reduces transfer of BDE47 from dam to murine offspring
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Long-term effects of environmentally relevant doses of 2,2 ',4,4 ',5,5 ' hexachlorobiphenyl (PCB153) on neurobehavioural development, health and spontaneous behaviour in maternally exposed mice
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Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies
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Beskyttende Effekt av Insulinterapi ved Iskemisk-Reperfusjon - effekten av insulin på mRNA-nivået til HIF-1α og apelin
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Allicin - Ekstrahert fra hvitløk (Allium sativum) Beskytter hjertet under hypoksi og ved reoksygenering
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MicroRNAs and the Ischaemic Heart - Novel Regulation of MicroRNAs at Reperfusion in Response to Insulin Therapy
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Effects of treatment with a 5-HT4 receptor antagonist in heart failure
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Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure : A quantitative RT-PCR study and the question of normalisation
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Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
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Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
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Insulin therapy appears to involve PKC and NFkB signaling when administered at reperfusion
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Normalization genes for gene expression studies in myocardium from mice, rats and humans
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Induction of functional serotonin 5-HT2A and 5-HT4 receptors in the acute failing cardiac ventricle
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Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle
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The 5-HT4 receptor - a foetal gene reactivated in heart failure?
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Treatment with a 5-HT4 serotonin receptor antagonist improves function of the failing heart
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Treatment with a 5-HT4 serotonin receptor antagonist improves function of the failing heart
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The 5-HT4 receptor - a foetal gene reactivated in heart failure?
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Characterisation and function of a novel serotonin receptor and the role of serotonin receptors in heart failure
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Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure
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Induction of a 5-HT4 receptor-mediated inotropic response to serotonin in failing ventricular cardiomyocytes
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Treatment of heart failure by blockade of ventricular myocardial serotonin receptors appearing in heart failure
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Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart
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Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants
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Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure
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Normalization genes for heart failure myocardium in mice, rats and humans
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The alpha1-AR mediated activation of NKCC in rat cardiomyocytes involves ERK dependent phosphorylation of the cotransporter
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Functional 5-HT receptors in human occipital artery
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Functional 5-HT receptors in human occipital artery
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Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
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Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure
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Induction of 5-HT4 receptor mediated inotropic response to serotonin in failing ventricular myocardium
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Novel effect of serotonin (5-HT) in heart faiure. A new therapeutic agent?
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Regulation of serotonin receptor mRNA levels in heart failure
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Novel effects of serotonin in heart failure
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Induction of serotonin receptors and inotropic effects in heart failure: a potential new neurohormonal target?
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Novel effect of serotonin (5-HT) in heart failure. A new therapeutic target
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Stabilisering av fisk ved prosedyrer ute av vann
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5-HT<SUB>4(a)</SUB> and 5-HT<SUB>4(b)</SUB> receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle
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Cardiac expression and pharmacological profile of human 5-HT<SUB>4</SUB> receptors
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Potential protein protein interactions with the unique intracellular carboxy tail of three 5-HT<SUB>4</SUB> receptor splice variants
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Refinement of fish research
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Guidelines for reporting the results of fish experiments
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Methods of positioning fish for surgery or other procedures out of water
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Pharmacological and immunological characterisation of human 5-HT4 receptor splice variants
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Pharmacological characterisation and cardiac expression of known and novel human 5-HT4 receptor splice variants
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Pharmacological and immunological characterisation of human 5-HT4 receptor splice variants
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Forsøksdyrlære for fiskeforskere